Dosimetry to evaluate the effect of Phosphoromidon on Lu-177-RM2

The human body is comprised of trillions of cells. In the healthy case, human cells divide naturally in a controlled manner in order to replace cells as needed. The process in which the body's cells divide continually in an unregulated fashion and thereby spread into surrounding tissues is known as cancer. Since the entire body is made up of cells, it is possible for this condition to occur anywhere in the body. The chance of an individual having this condition is related to their genetics as well as other factors. These tumor cells being formed will eventually combine to form larger cellular masses or "tumors." These tumors are split into two main categories known as "malignant" and "benign." Benign tumors do not spread into nearby tissue and can generally be easily removed. Malignant tumors or "cancerous tumors" can spread into nearby tissue and distant organs ultimately resulting in patient mortality. Once the cancer spreads from one region of the body to another it is called metastatic cancer because the process of transfer is known as metastasis. There are over 100 different forms of cancer. [7] The focus of this discussion will be prostate cancer

MS

thesisClimate change is projected to modify the hydrologic cycle across scales, but the relative impact climate change will have on water resources systems compared to other influencing factors remains uncertain. The performance of water storage reservoirs, for example, will not only be altered by climate-change-modified precipitation, runoff, evaporation, and transpiration, but also by additional factors such as water demand. Using a case study set in the western United States, this thesis presents an investigation of the relative importance of climate change modified hydrologic processes and water demand on reservoir feasibility. A modeling framework comprised of a river system model (MODSIM-DSS) and a precipitation (rainfall and snowfall) driven runoff model (Snowmelt Runoff Model) was created, calibrated and validated for the White River watershed and river system in northwest Colorado and northeast Utah. After validation, a proposed reservoir in the Utah segment of the White River was inserted into the modeling system. Based on climate change projections of impacts to hydrologic processes, scenarios reflecting climate change modified precipitation, temperature, and evaporation were defined and combined with a future water demand scenario including energy development and urban growth requirements. The scenarios were analyzed with the modeling system to quantify the relative impact of the altered hydrologic processes and increased water demand on reservoir feasibility. The results showed a reduction in precipitation has a greater effect than the projected increase in temperature and evaporation on the inflows to the proposed reservoir and performance of the reservoir. For a 7 percent decrease of precipitation there was an 8 percent reduction in runoff volume over a simulated ten-year period. This decrease was shown to have the greatest impact on the amount of water stored in the reservoir and the amount readily available for downstream use. In a simulation of the combined effects of precipitation, temperature and evaporation modification the reservoir was found to be impacted significantly with insufficient storage to meet downstream demands. Although significant, the impacts of the climate change modified hydrologic processes on reservoir feasibility were found to be insignificant compared to the impacts of future water demands

Active-Pixel Sensors With "Winner-Take-All" Mode

Circuits to generate the intensity reading and the coordinates of the brightest pixel in each image would be added to imaging photodetector arrays of the active-pixel-sensor (APS) type, according to a proposal. For a given APS, the additional circuitry for locating the brightest pixel would be installed at the periphery of the basic APS circuit. The additional circuitry would thus not degrade the original optical properties or interfere with the original electronic functions of the APS. The APS could be operated in its normal image-readout mode or, optionally, it could be operated with the additional circuitry in the brightest-pixel mode. Potential applications could include star tracking or fast tracking of a moving laser-beam spot in laser communication system

A Deep Dive into Understanding Tumor Foci Classification using Multiparametric MRI Based on Convolutional Neural Network

Deep learning models have had a great success in disease classifications using large data pools of skin cancer images or lung X-rays. However, data scarcity has been the roadblock of applying deep learning models directly on prostate multiparametric MRI (mpMRI). Although model interpretation has been heavily studied for natural images for the past few years, there has been a lack of interpretation of deep learning models trained on medical images. This work designs a customized workflow for the small and imbalanced data set of prostate mpMRI where features were extracted from a deep learning model and then analyzed by a traditional machine learning classifier. In addition, this work contributes to revealing how deep learning models interpret mpMRI for prostate cancer patients stratification

Geotechnical Observations of the November 3, 2002 M7.9 Denali Fault Earthquake

The M 7.9 earthquake of November 3, 2002 event ruptured more than 340 kilometers on three fault, causing widespread liquefaction in the fluvial deposits of steep alpine valleys of the Alaska Range and eastern lowlands of the Tanana River. The event occurred in a remote and largely undeveloped portion of the rugged Alaskan central range, with few seismometer recordings. The areas affected by liquefaction are largely confined to native Holocene river deposits, areas bounded by stiffer ground moraine, Pleistocene uplands, and bedrock. Liquefaction affected areas of alluvial river valleys draining mountainous and glacier-proximal rivers. The most noteworthy observations are that liquefaction damage was focused towards the eastern end of the rupture area. In the western portion of the rupture zone, localized liquefaction developed in recent deposits of the Susitna and Delta rivers in the immediate vicinity of the surface rupture of the fault. More abundant and severe liquefaction occurred on the eastern Robertson, Slana, Tok, Chisana and, especially, Nabesna Rivers. In the Tanana lowland, liquefaction features were sparse on the western bars of the Tanana River in the vicinity of Fairbanks to west of Delta, but became pervasive throughout the eastern region from Delta to Northway. Though liquefaction observations were abundant, there was a dearth of instrumental recordings useful to relate damage effects to measured intensity. To characterize soil properties and stiffness of liquefaction evaluation sites, we used a portable spectral analysis of surface waves (SASW) apparatus to profile the shear wave velocity of the ground. On the Nabesna and Delta rivers that cross the fault, we only observe liquefaction features in soil deposits where normalized shear wave velocities fall below 230 m/s. Severity of sand boils, fissuring and lateral displacement of liquefied ground dramatically increase in soils of lower shear wave velocity, especially below 170 m/s. Some of the most pronounced ground failures are far from the fault zone (60-100 km) in extremely loose, low velocity (~120 m/s) fine sands of the bars of the Tanana River. Strong motion instrumentation was sparse within 150 kilometers of the fault rupture and the seismometers of Alyeska pump stations PS9 (PGA=0.09), PS10 (PGA=0.36g), and PS11 (PGA=0.09) serve as the principal strong motion recordings. Insufficient strong motion instrumentation is available to identify areas of amplified ground motio

Volumetric and Voxel-Wise Analysis of Dominant Intraprostatic Lesions on Multiparametric MRI

Introduction: Multiparametric MR imaging (mpMRI) has shown promising results in the diagnosis and localization of prostate cancer. Furthermore, mpMRI may play an important role in identifying the dominant intraprostatic lesion (DIL) for radiotherapy boost. We sought to investigate the level of correlation between dominant tumor foci contoured on various mpMRI sequences. Methods: mpMRI data from 90 patients with MR-guided biopsy-proven prostate cancer were obtained from the SPIE-AAPM-NCI Prostate MR Classification Challenge. Each case consisted of T2-weighted (T2W), apparent diffusion coefficient (ADC), and K(trans) images computed from dynamic contrast-enhanced sequences. All image sets were rigidly co-registered, and the dominant tumor foci were identified and contoured for each MRI sequence. Hausdorff distance (HD), mean distance to agreement (MDA), and Dice and Jaccard coefficients were calculated between the contours for each pair of MRI sequences (i.e., T2 vs. ADC, T2 vs. K(trans), and ADC vs. K(trans)). The voxel wise spearman correlation was also obtained between these image pairs. Results: The DILs were located in the anterior fibromuscular stroma, central zone, peripheral zone, and transition zone in 35.2, 5.6, 32.4, and 25.4% of patients, respectively. Gleason grade groups 1-5 represented 29.6, 40.8, 15.5, and 14.1% of the study population, respectively (with group grades 4 and 5 analyzed together). The mean contour volumes for the T2W images, and the ADC and K(trans) maps were 2.14 +/- 2.1, 2.22 +/- 2.2, and 1.84 +/- 1.5 mL, respectively. K(trans) values were indistinguishable between cancerous regions and the rest of prostatic regions for 19 patients. The Dice coefficient and Jaccard index were 0.74 +/- 0.13, 0.60 +/- 0.15 for T2W-ADC and 0.61 +/- 0.16, 0.46 +/- 0.16 for T2W-K(trans). The voxel-based Spearman correlations were 0.20 +/- 0.20 for T2W-ADC and 0.13 +/- 0.25 for T2W-K(trans). Conclusions: The DIL contoured on T2W images had a high level of agreement with those contoured on ADC maps, but there was little to no quantitative correlation of these results with tumor location and Gleason grade group. Technical hurdles are yet to be solved for precision radiotherapy to target the DILs based on physiological imaging. A Boolean sum volume (BSV) incorporating all available MR sequences may be reasonable in delineating the DIL boost volume

Executing Practices

In this chapter we discuss how the edited collection "Executing Practices" brings attention to what Isabelle Stengers (2005) describes as the particular demands of practices that propel execution. Practices are parsed as processes by which execution stabilises and takes hold in the world (Stengers, in Gabrys 2016, 9). Rather than considering the stability of execution as the norm, which we might approach with dystopic or paranoid dread, the authors in the book engage with and make interventions on the problems of execution. We outline that "Executing Practices" alerts us that access to instructions that drive execution is only one account, and even then, our understanding of execution might always remain partial and speculative